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KMID : 0369820140440060455
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Jorunal of Korean Pharmaceutical Sciences
2014 Volume.44 No. 6 p.455 ~ p.463
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Sustained delivery of cefdinir to upper gastrointestinal tract using calcium alginate beads: a formulation by design
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Praveen Radhakrishnan
Sandeep Kumar Singh
Verma Priya Ranjan Prasad
George Jerome Karippamattom
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Abstract
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The present research demonstrates the development and characterization of alginate based multiunit floating dosage form for sustained delivery of cefdinir to the upper gastrointestinal tract. The method involved ionic gelation of sodium alginate solution containing suspended drug and myristyl alcohol (release modifier and buoyancy regulator) by calcium ions followed by freeze drying. Fourier transform infrared spectroscopy and differential scanning calorimetry studies revealed that there were no incompatibilities between drug and excipients. The effect of various process variables; amount of sodium alginate, myristyl alcohol and cefdinir; on critical parameters like drug loading, particle size and mean dissolution time (MDT) was modelled using Box?Behnken design and studied using response surface plots and regression equations. The observed and predicted r2 values were in agreement in case of all the responses which marks the validity of developed model. The particle size, drug loading and MDT were found to be strongly dependent on the variables studied. The beads showed high drug loading up to 65.41 % and extended drug release up to 24 h in 0.1 N hydrochloric acid. The beads exhibited 100 % buoyancy without any lag time up to 24 h despite of the high drug loading. The mechanism of drug release was found to be Fickian diffusion.
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KEYWORD
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Floating dosage form, Gastroretentive, Alginate bead, Ionic gelation, Sustained release
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